Abstract #4905

Resting-state based Cerebrovascular Reactivity (CVR) mapping at high spatial resolutions

Lincoln Kartchner¹, Dengrong Jiang², Parimal Joshi¹, Cuimei Xu², Hanzhang Lu², and Peiying Liu¹

¹Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, ²Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Cerebrovascular reactivity (CVR) is typically assessed with a carbon dioxide (CO₂) stimulus combined with BOLD fMRI.Recently, resting-state BOLD fMRI has been shown capable of generating CVR maps, providing a potential for broader CVR applications in neuroimaging studies. However, prior RS-CVR studies have primarily been performed at a spatial resolution of 3-4mm³ voxel sizes. It remains unknown whether RS-CVR can also be obtained at high-resolution without major degradation in image quality. In this study, we investigated the feasibility of high-resolution CVR mapping based on resting-state fMRI data. Our results showed good CVR quality can be obtained at 2-3mm³ voxel sizes.

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