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Abstract #4905

Resting-state based Cerebrovascular Reactivity (CVR) mapping at high spatial resolutions

Lincoln Kartchner1, Dengrong Jiang2, Parimal Joshi1, Cuimei Xu2, Hanzhang Lu2, and Peiying Liu1
1Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, 2Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States


Cerebrovascular reactivity (CVR) is typically assessed with a carbon dioxide (CO2) stimulus combined with BOLD fMRI. Recently, resting-state BOLD fMRI has been shown capable of generating CVR maps, providing a potential for broader CVR applications in neuroimaging studies. However, prior RS-CVR studies have primarily been performed at a spatial resolution of 3-4mm3 voxel sizes. It remains unknown whether RS-CVR can also be obtained at high-resolution without major degradation in image quality. In this study, we investigated the feasibility of high-resolution CVR mapping based on resting-state fMRI data. Our results showed good CVR quality can be obtained at 2-3mm3 voxel sizes.

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