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Abstract #4918

Heart-brain MRI evaluation in one exam: a feasibility study in healthy aging adults

Kelly Jarvis1, Jackson E Moore1, Maria Aristova1, Ning Jin2, Valerie Torres1, Susanne Schnell1,3, Eric Russell1, Michael Markl1, Emily Rogalski4, and Ann Ragin1
1Radiology, Northwestern University, Chicago, IL, United States, 2Siemens Medical Solutions Inc., Cleveland, OH, United States, 3Medical Physics, University of Greifswald, Greifswald, Germany, 4Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL, United States

Synopsis

Mechanisms underlying heart-brain hemodynamic coupling and effects on the brain remain unclear due to challenges of measuring both heart and brain in a single MRI exam. We have developed a comprehensive MRI protocol that incorporates 1) 4D flow MRI of chest, 2) 4D flow MRI of head and 3) structural neuroimaging into one MRI exam to assess cardiovascular and cerebrovascular flow as well as white matter lesions and brain atrophy. This study demonstrates the utility of heart-brain MRI as viable new tool for in vivo evaluation of hemodynamic coupling along the entire heart-brain pathway.

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