Mechanisms underlying heart-brain hemodynamic coupling and effects on the brain remain unclear due to challenges of measuring both heart and brain in a single MRI exam. We have developed a comprehensive MRI protocol that incorporates 1) 4D flow MRI of chest, 2) 4D flow MRI of head and 3) structural neuroimaging into one MRI exam to assess cardiovascular and cerebrovascular flow as well as white matter lesions and brain atrophy. This study demonstrates the utility of heart-brain MRI as viable new tool for in vivo evaluation of hemodynamic coupling along the entire heart-brain pathway.
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