Cerebral amyloid angiopathy (CAA) is characterized by deposition of amyloid-β protein in the walls of cortical and leptomemingeal small vessels. CAA is common in community-based older adults and has been associated with cognitive decline and dementia. To date, the association of CAA with the transverse relaxation rate, R2, remains unknown. This study in a large number of autopsied brains from community-based older adults showed for the first time that CAA is associated with higher R2, independent of other neuropathologies and demographic factors. The spatial pattern for this association derived from voxel-wise analysis included subcortical and frontal lobe structures.
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