Abstract #4931

Cerebral Amyloid Angiopathy (CAA) is associated with higher R2 relaxation rate: An ex-vivo MRI and pathology study

Md Tahmid Yasar¹, Mahir Tazwar ¹, Ashish A. Tamhane², Arnold M. Evia², David A. Bennett², Julie A. Schneider², and Konstantinos Arfanakis^1,2

¹Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, ²Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States

Synopsis

Cerebral amyloid angiopathy (CAA) is characterized by deposition of amyloid-β protein in the walls of cortical and leptomemingeal small vessels. CAA is common in community-based older adults and has been associated with cognitive decline and dementia. To date, the association of CAA with the transverse relaxation rate, R₂, remains unknown. This study in a large number of autopsied brains from community-based older adults showed for the first time that CAA is associated with higher R₂, independent of other neuropathologies and demographic factors. The spatial pattern for this association derived from voxel-wise analysis included subcortical and frontal lobe structures.

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