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Abstract #4933

A randomized controlled trial of statins to reduce inflammation in cerebral aneurysms using vessel wall MRI

Chengcheng Zhu1, Huibin Kang2, Decai Tian3, Mahmud Mossa-basha1, Michael Levitt4, David Hasan5, Xinjian Yang2, and Yisen Zhang2
1Radiology, University of Washington, Seattle, WA, United States, 2Neurosurgery, Tiantan Hospital, Beijing, China, 3Neurology, Tiantan Hospital, Beijing, China, 4Neurosurgery, University of Washington, Seattle, WA, United States, 5Neurosurgery, University of Iowa, Iowa, IA, United States

Synopsis

Aneurysm wall enhancement as shown on contrast-enhanced vessel wall MRI (VW-MRI) is a surrogate biomarker of intracranial aneurysm (IA) wall inflammation, and it is associated with IA symptoms, growth, and rupture. However, it hasn't been used in clinical trails for UIA treatment. We performed the first prospective randomized controlled trial on the effect of statins for changes in aneurysm wall enhancement as shown in VW-MRI. We found that statins decreased aneurysm wall enhancement of UIAs in a short term of 6 months. Our results suggest VWI-MRI has great potential in future image-guided clinical trails to investigate novel treatment of IAs.

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