Abstract #4933

A randomized controlled trial of statins to reduce inflammation in cerebral aneurysms using vessel wall MRI

Chengcheng Zhu¹, Huibin Kang², Decai Tian³, Mahmud Mossa-basha¹, Michael Levitt⁴, David Hasan⁵, Xinjian Yang², and Yisen Zhang²

¹Radiology, University of Washington, Seattle, WA, United States, ²Neurosurgery, Tiantan Hospital, Beijing, China, ³Neurology, Tiantan Hospital, Beijing, China, ⁴Neurosurgery, University of Washington, Seattle, WA, United States, ⁵Neurosurgery, University of Iowa, Iowa, IA, United States

Synopsis

Aneurysm wall enhancement as shown on contrast-enhanced vessel wall MRI (VW-MRI) is a surrogate biomarker of intracranial aneurysm (IA) wall inflammation, and it is associated with IA symptoms, growth, and rupture. However, it hasn't been used in clinical trails for UIA treatment. We performed the first prospective randomized controlled trial on the effect of statins for changes in aneurysm wall enhancement as shown in VW-MRI. We found that statins decreased aneurysm wall enhancement of UIAs in a short term of 6 months. Our results suggest VWI-MRI has great potential in future image-guided clinical trails to investigate novel treatment of IAs.

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