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Abstract #4935

Characterization of a novel rodent model of arteriovenous malformations (AVMs) with time-of-flight magnetic resonance angiography

Chul Han1, Gregory Harrison Turner2, Candice Nguyen1, Michael Lawton1, and S. Paul Oh1
1Barrow Aneurysm and AVM Research Center, Barrow Neurological Institute, Phoenix, AZ, United States, 2Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States

Synopsis

A mouse model of arteriovenous malformations was developed with a genetics-based approach that conditionally deleted the causative activin receptor-like kinase 1 (ACVRL1 or ALK1) gene. This model was characterized in vivo using time-of-flight angiography (TOF_MRA). We correlated radiographic and histopathologic findings and determined that the 55 Tagln-Cre (+);Alk12f/2f mouse was a promising experimental brain AVM model for future studies of AVM pathophysiology, growth, rupture, and therapeutic regression.

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Keywords