A mouse model of arteriovenous malformations was developed with a genetics-based approach that conditionally deleted the causative activin receptor-like kinase 1 (ACVRL1 or ALK1) gene. This model was characterized in vivo using time-of-flight angiography (TOF_MRA). We correlated radiographic and histopathologic findings and determined that the 55 Tagln-Cre (+);Alk12f/2f mouse was a promising experimental brain AVM model for future studies of AVM pathophysiology, growth, rupture, and therapeutic regression.
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