Abstract #4937

Implementation of OxFlow MRI with concurrent EEG for tracking the cerebral metabolic rate of oxygen during extended-duration scans of sleep

Alexander M Barclay¹, Alessandra S Caporale¹, Hengyi Rao¹, Hyunyeol Lee², Michael C Langham¹, and Felix W Wehrli¹

¹University of Pennsylvania, Philadelphia, PA, United States, ²Kyungpook National University, Daegu, Korea, Republic of

Synopsis

OxFlow was used to track the global cerebral metabolic rate of oxygen (CMRO₂) during wakefulness and sleep, with concurrent EEG, in eleven healthy subjects scanned continuously for 80 minutes. CMRO₂ was derived from phase-contrast measurements of cerebral blood flow (CBF) in the neck with susceptometry-based oximetry measurements of venous oxygenation (SvO₂) in the superior sagittal sinus (SSS). Results reveal that there is negligible bias between total CBF (tCBF), obtained by upscaling the value measured in the SSS, and CBF measured at the neck, suggesting that single-slice OxFlow can be implemented to simplify data acquisition and processing without sacrificing accuracy.

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