OxFlow was used to track the global cerebral metabolic rate of oxygen (CMRO2) during wakefulness and sleep, with concurrent EEG, in eleven healthy subjects scanned continuously for 80 minutes. CMRO2 was derived from phase-contrast measurements of cerebral blood flow (CBF) in the neck with susceptometry-based oximetry measurements of venous oxygenation (SvO2) in the superior sagittal sinus (SSS). Results reveal that there is negligible bias between total CBF (tCBF), obtained by upscaling the value measured in the SSS, and CBF measured at the neck, suggesting that single-slice OxFlow can be implemented to simplify data acquisition and processing without sacrificing accuracy.
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