Abstract #4942

High Prevalence of Abnormal 3T MRI Findings in Clinically Asymptomatic Siblings of Patients with Osteochondritis Dissecans of the Knee

Abdul Wahed Kajabi^1,2, Stefan Zbyn^1,2, Marc A. Tompkins³, Bradley J. Nelson³, Kevin G. Shea⁴, Cathy S. Carlson⁵, and Jutta M. Ellermann^1,2

¹Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, ²Department of Radiology, University of Minnesota, Minneapolis, MN, United States, ³Department of Orthopedic Surgery, University of Minnesota, Minneapolis, MN, United States, ⁴Stanford Children's Hospital, Stanford University, Palo Alto, CA, United States, ⁵Department of Veterinary Medicine, University of Minnesota, St. Paul, MN, United States

Synopsis

This study examined seven clinically asymptomatic siblings of patients with Osteochondritis Dissecans (OCD) utilizing 3T MRI, including quantitative apparent diffusion coefficient (ADC) mapping to evaluate morphological integrity of the epiphyseal cartilage, integrity of secondary physis and trabecular bone quality in the distal femoral condyles of bilateral knees. A high prevalence (86%) of morphological MRI abnormalities that can be seen in early OCD and increased diffusivity (high quantitative ADC values) in trabecular bone were detected. The high prevalence of early signs of OCD in clinically asymptomatic siblings of OCD patients supports evidence of a genetic predisposition for the disease.

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