Abstract #4958

Intranasal Insulin Enhances Resting Neurovascular Fluctuations in Type 2 Diabetes

Zongpai Zhang¹, Faizan Khan², Peter Novak², Christos Mantzoros³, Long Ngo³, Vera Novak², and Weiying Dai¹

¹State University of New York at Binghamton, Binghamton, NY, United States, ²Department of Neurology, Harvard Medical School, Boston, ME, United States, ³Department of Medicine, Harvard Medical School, Boston, ME, United States

Synopsis

We aimed to investigate the effect of intranasal insulin (INI) on cognition, balance, and brain neurovascular activity in type 2 diabetes mellitus (T2DM) participants of the MemAID trial. Cognition, balance, and brain neurovascular fluctuations - amplitude of low-frequency fluctuations (ALFF) were measured in 11 subjects before and after 24-week treatment with INI or placebo. INI treatment significantly increased ALFF in the medial-frontal region. The ALFF increases at the end-of INI treatment were associated with improved balance. These findings suggest that INI may increase brain neurovascular activity in T2DM in the regions related to balance control and sustained attention.

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