Abstract #4958

Intranasal Insulin Enhances Resting Neurovascular Fluctuations in Type 2 Diabetes

Zongpai Zhang¹, Faizan Khan², Peter Novak², Christos Mantzoros³, Long Ngo³, Vera Novak², and Weiying Dai¹

¹State University of New York at Binghamton, Binghamton, NY, United States, ²Department of Neurology, Harvard Medical School, Boston, ME, United States, ³Department of Medicine, Harvard Medical School, Boston, ME, United States

Synopsis

We aimed to investigate the effect of intranasal insulin (INI) on cognition, balance, and brain neurovascular activity in type 2 diabetes mellitus (T2DM) participants of the MemAID trial. Cognition, balance, and brain neurovascular fluctuations - amplitude of low-frequency fluctuations (ALFF) were measured in 11 subjects before and after 24-week treatment with INI or placebo. INI treatment significantly increased ALFF in the medial-frontal region. The ALFF increases at the end-of INI treatment were associated with improved balance. These findings suggest that INI may increase brain neurovascular activity in T2DM in the regions related to balance control and sustained attention.

This abstract and the presentation materials are available to members only; a login is required.

Join Here