Evidence supports that the virus SARS-CoV-2 has a potential neuroinvasion causing neurological symptoms, even after recovery. Diffusion Weighted Imaging (DWI) allows us to detect the microstructural changes in white matter tissue integrity. In this work, we studied the neurological manifestations of COVID-19 in apparent diffusion coeficient (ADC), fractional anisotropy (FA), and metrics derived from fixel-based analysis (FBA) such as fiber density (FD), fiber cross-section (FC), and fiber density and cross-section (FDC). We found statistically significant differences in 34/43 fiber bundle regions from the IIT Human Brain Atlas in the five different metrics studied.
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