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Abstract #4963

Analysis of white matter tissue integrity of COVID-19 recovered patients using diffusion weighted imaging

Alejandro Santos-Díaz1,2, Berenice Sanchez-Alvarado3, Oscar Marrufo Melendez4, Roger Carrillo Mezo4, Antonio Arauz Gongora4, and Monica Rodriguez5
1School of Engineering and Science, Tecnologico de Monterrey, Mexico City, Mexico, 2School of Medicine and Health Sciences, Tecnologico de Monterrey, Monterrey, Mexico, 3School of Engineering and Science, Tecnologico de Monterrey, Monterrey, Mexico, 4Neuroimaging, Instituto Nacional de Neurologia y Neurocirugía, Mexico City, Mexico, 5Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico

Synopsis

Evidence supports that the virus SARS-CoV-2 has a potential neuroinvasion causing neurological symptoms, even after recovery. Diffusion Weighted Imaging (DWI) allows us to detect the microstructural changes in white matter tissue integrity. In this work, we studied the neurological manifestations of COVID-19 in apparent diffusion coeficient (ADC), fractional anisotropy (FA), and metrics derived from fixel-based analysis (FBA) such as fiber density (FD), fiber cross-section (FC), and fiber density and cross-section (FDC). We found statistically significant differences in 34/43 fiber bundle regions from the IIT Human Brain Atlas in the five different metrics studied.

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Abstract