Abstract #4965
Dose-Escalated Radiation Treatment Plans in Glioblastoma Based on Quantitative Magnetization Transfer using a 1.5T MR-Linac
Rachel W. Chan1, Mark Ruschin2, Liam S.P. Lawrence3, James Stewart2, Sten Myrehaug2, Chia-Lin Tseng2, Jay Detsky2, Pejman J. Maralani4, Mary Jane Lim-Fat2, Hany Soliman2, Greg J. Stanisz1,3,5, Arjun Sahgal2, and Angus Z. Lau1,3
1Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada, 2Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 3Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 4Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada, 5Department of Neurosurgery and Pediatric Neurosurgery, Medical University of Lublin, Lublin, Poland
Synopsis
Hybrid MR/radiotherapy MR-Linac devices enable dose adaptation based on daily imaging. Saturation transfer MRI, including quantitative magnetization transfer (qMT) and chemical exchange saturation transfer (CEST), have been shown to predict treatment response in glioblastoma. Here, in a proof-of-principle study, we demonstrated the feasibility of retrospectively generating dose-escalated radiation plans based on qMT semi-solid fraction maps acquired on the MR-Linac. Treatment plans with a 115-120% boost dose were successfully generated in all four patients and adhered to clinical organs-at-risk dose constraints.
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