Abstract #4965

Dose-Escalated Radiation Treatment Plans in Glioblastoma Based on Quantitative Magnetization Transfer using a 1.5T MR-Linac

Rachel W. Chan¹, Mark Ruschin², Liam S.P. Lawrence³, James Stewart², Sten Myrehaug², Chia-Lin Tseng², Jay Detsky², Pejman J. Maralani⁴, Mary Jane Lim-Fat², Hany Soliman², Greg J. Stanisz^1,3,5, Arjun Sahgal², and Angus Z. Lau^1,3

¹Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada, ²Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ³Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ⁴Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada, ⁵Department of Neurosurgery and Pediatric Neurosurgery, Medical University of Lublin, Lublin, Poland

Synopsis

Hybrid MR/radiotherapy MR-Linac devices enable dose adaptation based on daily imaging. Saturation transfer MRI, including quantitative magnetization transfer (qMT) and chemical exchange saturation transfer (CEST), have been shown to predict treatment response in glioblastoma. Here, in a proof-of-principle study, we demonstrated the feasibility of retrospectively generating dose-escalated radiation plans based on qMT semi-solid fraction maps acquired on the MR-Linac. Treatment plans with a 115-120% boost dose were successfully generated in all four patients and adhered to clinical organs-at-risk dose constraints.

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