Abstract #4967

Diffusion Tensor Imaging Biomarkers for Chronic Pain Following Mild Traumatic Injury

Ho-Ching Yang¹, Kelly Naugle², Qiuting Wen¹, Fletcher A White^3,4,5, and Yu-Chien Wu¹

¹Departments of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, ²Department of Kinesiology, School of Health and Human Sciences, Indiana University Purdue University Indianapolis, Indianapolis, IN, United States, ³Department of Anesthesia, School of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States, ⁴Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN, United States, ⁵Research and Development Services, Richard L. Roudebush VA Medical Center, Indianapolis, IN, United States

Synopsis

To investigate the neuropathogenesis of post-traumatic headache following mild traumatic brain injuries (mTBI), this study applied diffusion tensor imaging and functional magnetic resonance imaging to explore relationships between brain structural and functional changes and sensitization, pain inhibitory capacity, psychological factors and headache pain in mTBI subjects. The results found structural and functional alterations in mTBI. Also, the results showed that DTI metric differences between mTBI subjects and controls can be used to predict pain/psychological measurements, which indicated the relationship between white matter disruption and measurements of endogenous pain modulation and psychological distress in mTBI.

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