Alzheimer’s disease (AD) is a neurodegenerative disease and the most common cause of dementia among older adults. We implemented 3D Zernike transformation to characterize the shape changes of hippocampus in 428 older subjects with high-quality T1-weighted volumetric brain scans. The hippocampus shape features characterized with 3D Zernike transformation, in complement to volume measures, may serve as a novel imaging marker to monitor clinical AD progression.
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