Abstract #4973

Hippocampus Shape Characterization with 3D Zernike Transformation in Clinical Alzheimer’s Disease Progression

David C Zhu¹, Chih-Ying Gwo², An-Wen Deng², Norman Scheel¹, Mari A Dowling¹, and Rong Zhang³

¹Michigan State University, East Lansing, MI, United States, ²Chien Hsin University of Science and Technology, Taoyuan, Taiwan, ³University of Texas Southwestern Medical Center, Dallas, TX, United States

Synopsis

Alzheimer’s disease (AD) is a neurodegenerative disease and the most common cause of dementia among older adults. We implemented 3D Zernike transformation to characterize the shape changes of hippocampus in 428 older subjects with high-quality T₁-weighted volumetric brain scans. The hippocampus shape features characterized with 3D Zernike transformation, in complement to volume measures, may serve as a novel imaging marker to monitor clinical AD progression.

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