Quantitative magnetization transfer (QMT) imaging using the selective inversion recovery (SIR) approach has been successful in estimating fundamental tissue parameters, such as the PSR (macromolecular-to-free proton pool size ratio) and the R1f (relaxation rate of the free pool). Although SIR allows one to perform the QMT experiment using conventional inversion recovery sequences, it is hampered by long scan times. Previously we have shown that Compressed SENSE (CS-SENSE) accelerates whole-brain SIR-QMT imaging, allowing whole-brain scanning within clinically practical scan times. In this study, we systematically investigate the effect of this acceleration on test-retest repeatability for PSR and R1f.
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