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Abstract #5004

Multi-site harmonization of diffusion MRI data from the Adolescent Brain Cognitive Development (ABCD) Study

Suheyla Cetin-Karayumak1, Fan Zhang1, Steve Pieper2, Lauren J. O'Donnell1, and Yogesh Rathi1
1Harvard Medical School and Brigham and Women's Hospital, Boston, MA, United States, 2Isomics, Cambridge, MA, United States

Synopsis

This study presents our harmonization efforts on the multi-site diffusion MRI data from ~11,000 adolescents in the Adolescent Brain Cognitive Development (ABCD) study, collected at 21 sites using Siemens, GE, and Philips scanners. We validated the harmonization of the multi-site dMRI data using several standard and advanced diffusion MRI measures including Fractional Anisotropy (FA), Return-To-Origin Probability (RTOP), Return To the Axis Probability (RTAP), Return To the Plane Probability (RTPP), Mean Squared Displacement (MSD).

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Keywords