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Abstract #5006

Quality Assessment of Mouse fMRI: Evaluating Temporal Stability of Preclinical Scanners

Mila Urosevic1, Jeremie Fouquet2, and M. Mallar Chakravarty1,2,3
1Biological & Biomedical Engineering, McGill University, Montreal, QC, Canada, 2Douglas Mental Health University Institute, Montreal, QC, Canada, 3Department of Psychiatry, McGill University, Montreal, QC, Canada

Synopsis

Mouse functional magnetic resonance imaging (fMRI) has interesting potential for basic neuroscience, but there is significant variability in data quality across studies. This variability may be partly explained by differences in scanner stability, however there are no reports of scanner quality assessments in the mouse fMRI field. We evaluated the stability of our preclinical scanner by acquiring an fMRI time-series of an agarose phantom then computing stability metrics. We found that our scanner has acceptable temporal stability but unexpected periodic fluctuations. Our methods are openly available so that other groups can easily implement stability assessments on their respective preclinical scanners.

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