Abstract #5009

Myelin Imaging Using 3D Dual-echo Ultra-short Echo Time MRI with Rosette k-Space Pattern

Xin Shen¹, Ali Caglar Özen², Antonia Sunjar¹, Serhat Ilbey², Riyi Shi^1,3, Mark Chiew⁴, and Uzay Emir^1,5

¹Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States, ²Department of Radiology, Medical Physics, University of Freiburg, Freiburg, Germany, ³College of Veterinary Medicine, Purdue University, West Lafayette, IN, United States, ⁴Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom, ⁵Health Science Department, Purdue University, West Lafayette, IN, United States

Synopsis

This study aimed to develop a new 3D dual-echo rosette k-space trajectory, specifically for applications of ultra-short echo time (UTE) magnetic resonance imaging (MRI). The direct imaging of the myelin bilayer, which has ultra-short transverse relaxation time (uT₂), was acquired to test the performance of the proposed UTE sequence. The rosette trajectory was developed based on rotations of a ‘petal-like’ pattern in the k_x-k_y plane, with oscillated extensions in k_z-direction for 3D coverage. The higher uT₂ fraction value in white matter (WM) compared to grey matter (GM) demonstrated the ability of the proposed sequence to capture rapidly decaying signals.

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