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Abstract #5023

Application of the template-based attenuation correction to simultaneous MR-PET brain imaging of non-human primates

Chi-Hyeon Yoo1, Jonathan DuBois2, Lu Wang3, Steven Liang4, David Izquierdo-Garcia1, and Hsiao-Ying Wey1
1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States, 2Biogen, Cambridge, MA, United States, 3Department of Nuclear Medicine and PET/CT-MRI Center, The First Affiliated Hospital of Jinan University & Institute of Molecular and Functional Imaging, Jinan University, Guangzhou, China, 4Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States

Synopsis

The goal of this study was to generate a population-based template/atlas and apply the template/atlas-based attenuation correction (AC) method for simultaneous positron-emission-tomography/magnetic-resonance-imaging (PET/MRI) neuroimaging studies on non-human primates (NHPs). Population-based template/atlas of computed tomography image and anatomical MRI, were generated from ten NHPs (rhesus macaque). By using the generated template/atlas, the linear attenuation coefficient (LAC) of objects can be reliably derived, showing good differentiation for tissues, also skull and air. Comparison of the PET images reconstructed by the template/atlas-based and simple threshold-based AC has shown that the template/atlas-based AC can increase PET signal by avoiding overcompensation of attenuation.

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Abstract