Abstract #5023

Application of the template-based attenuation correction to simultaneous MR-PET brain imaging of non-human primates

Chi-Hyeon Yoo¹, Jonathan DuBois², Lu Wang³, Steven Liang⁴, David Izquierdo-Garcia¹, and Hsiao-Ying Wey¹

¹Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States, ²Biogen, Cambridge, MA, United States, ³Department of Nuclear Medicine and PET/CT-MRI Center, The First Affiliated Hospital of Jinan University & Institute of Molecular and Functional Imaging, Jinan University, Guangzhou, China, ⁴Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States

Synopsis

The goal of this study was to generate a population-based template/atlas and apply the template/atlas-based attenuation correction (AC) method for simultaneous positron-emission-tomography/magnetic-resonance-imaging (PET/MRI) neuroimaging studies on non-human primates (NHPs). Population-based template/atlas of computed tomography image and anatomical MRI, were generated from ten NHPs (rhesus macaque). By using the generated template/atlas, the linear attenuation coefficient (LAC) of objects can be reliably derived, showing good differentiation for tissues, also skull and air. Comparison of the PET images reconstructed by the template/atlas-based and simple threshold-based AC has shown that the template/atlas-based AC can increase PET signal by avoiding overcompensation of attenuation.

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