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Abstract #5045

PET Recon with MR Priors: Application in Ambiguously Rated Amyloid PET Scans

Mehdi Khalighi1, Greg Zaharchuk1, Michael Zeineh1, Guido Davidzon1, Gabriel Kennedy2, Christina Young1, Michael Greicius2, Kathleen Poston2, and Elizabeth Mormino2
1Radiology, Stanford University, Stanford, CA, United States, 2Neurology, Stanford University, Stanford, CA, United States

Synopsis

A recently developed PET recon with MR priors and motion correction method is applied to a set of ambiguously rated amyloid PET scans and is compared with regular TOF-OSEM PET recon using SUVR. The same comparison is done in a set of scans which were matched by clinical diagnosis. By using PET recon with MR priors, lower SUVRs for negative scans compared to increased SUVRs for positive scans were measured, which shows improvement in the ability to distinguish intermediate amyloid levels.

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