Abstract #0001

Pulmonary MRI & Cluster Analysis Help Identify Novel Asthma Phenotypes

Rachel L. Eddy^1,2, Marrissa J McIntosh³, Alexander M Matheson³, David G McCormack⁴, Christopher Licskai⁴, and Grace Parraga⁵

¹Centre for Heart Lung Innovation, St. Paul’s Hospital, University of British Columbia, Vancouver, BC, Canada, ²Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada, ³Robarts Research Institute, Department of Medical Biophysics, Western University, London, ON, Canada, ⁴Division of Respirology, Department of Medicine, Western University, London, ON, Canada, ⁵Robarts Research Institute, Department of Medical Biophysics; Division of Respirology, Department of Medicine, Western University, London, ON, Canada

Synopsis

Keywords: YIA, LungPulmonary functional MRI measurements have never been evaluated for the generation of imaging-based asthma patient clusters, although computed tomography (CT)-based clusters have been determined. Here we investigated hyperpolarized ¹²⁹XeMRI ventilation in combination with CT airway measurements in 45 patients with asthma and identified 4 phenotypic clusters with distinct structure-function and clinical characteristics. Our results revealed a novel cluster of patients only distinguished by MRI ventilation measurements, underscoring the utility of MRI to discriminate airway pathologies in asthma. Imaging-based clusters of asthma provide novel structure-function insights that may be exploited in future studies and challenge current clinical paradigms for asthma phenotyping.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.