Abstract #0004

Measurement of Magnetostimulation Thresholds in the Porcine Heart

Valerie Klein^1,2,3, Jaume Coll-Font^2,3,4, Livia Vendramini², Donald Staney², Mathias Davids^2,3, Natalie G. Ferris^2,5, Lothar R. Schad^1,6, David E. Sosnovik^2,3,4,5, Christopher Nguyen^7,8,9, Lawrence L Wald^2,3,5, and Bastien Guérin^2,3

¹Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany, ²A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, ³Harvard Medical School, Boston, MA, United States, ⁴Cardiovascular Research Center, Cardiology Division, Massachusetts General Hospital, Charlestown, MA, United States, ⁵Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, United States, ⁶Mannheim Institute for Intelligent Systems in Medicine, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany, ⁷Cardiovascular Innovation Research Center, Heart Vascular & Thoracic Institute, Cleveland Clinic, Cleveland, OH, United States, ⁸Department of Radiology, Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, ⁹Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States

Synopsis

Keywords: YIA, HeartHigh-amplitude gradient systems can surpass the IEC regulatory limit for cardiac stimulation (CS), which is based on animal electrostimulation data and simplified electromagnetic modeling. We assess CS in MRI by performing the first cardiac magnetostimulation threshold measurements in pigs, the primary animal model of the human cardiovascular system. We use the measurements to validate a detailed CS modeling pipeline applicable to both pigs and humans. Experimental thresholds and predictions in porcine-specific models agree within 19% NRMSE. CS modeling in a detailed human body model indicates that CS thresholds of the Connectome gradient are ~25-fold greater than the IEC CS limit.

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