Abstract #0005

Whole-Abdomen Metabolic Imaging of Health Volunteers Using Hyperpolarized [1-13C]pyruvate MRI

Philip Meng-en Lee¹, Hsin-Yu Chen², Jeremy W. Gordon², Zhen J Wang², Robert Bok², Ralph Hashoian³, Yaewon Kim², Xiaoxi Liu², Tanner Nickles¹, Kiersten Cheung², Francesca De Las Alas², Heather Daniel², Peder EZ Larson¹, Cornelius von Morze⁴, Daniel B Vigneron¹, and Michael A Ohliger^2,5

¹UC Berkeley-UCSF Graduate Program in Bioengineering; Dept. of Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²Department of Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ³Clinical MR Solutions, Brookfield, WI, United States, ⁴Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, United States, ⁵Department of Radiology and Biomedical Imaging, Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, CA, United States

Synopsis

Keywords: YIA, Hyperpolarized MR (Non-Gas), Body - LiverWhole-abdomen imaging with hyperpolarized ¹³C is challenging due to B₀ and B₁ inhomogeneities, respiratory motion, and broad spatial coverage. There is also little baseline data about healthy metabolism in abdominal organs. We developed and describe here a reliable imaging method to overcome these challenges, enabling metabolic imaging of the entire abdomen in a series of healthy volunteers. We present observed conversation rates of HP [1-¹³C]pyruvate to lactate and alanine in key organs such as the liver, kidneys, pancreas, and spleen. Methods established here set a firm foundation for investigating a broad spectrum of metabolic and neoplastic abnormalities in the liver.

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