Abstract #0006

Predicting the Onset of Ischemic Stroke with Fast High-Resolution 3D MR Spectroscopic Imaging

Zengping Lin¹, Ziyu Meng¹, Tianyao Wang², Rong Guo^3,4, Yibo Zhao^3,5, Yudu Li^3,5, Bin Bo¹, Yue Guan¹, Jun Liu², Hong Zhou⁶, Xin Yu⁷, David J Lin⁸, Zhi-Pei Liang^3,5, Parashkev Nachev⁹, and Yao Li¹

¹School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ²Radiology Department, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China, ³Beckman Institute for Advanced Science & Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁴Siemens Medical Solutions USA, Inc, Urbana, IL, United States, ⁵Department of Electrical & Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁶Department of Radiology, The First Affiliated Hospital of South China of University, South China of University, Hengyang, China, ⁷Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ⁸Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, ⁹Institute of Neurology, University College London, London, United Kingdom

Synopsis

Keywords: YIA, IschemiaNeurometabolite concentrations provide a direct index of infarct progression in stroke, but their relationship with stroke onset time remains unclear. Using a fast high-resolution 3D MRSI technique, this study assessed the temporal dynamics of N-acetylaspartate (NAA), creatine, choline, and lactate and estimated their value in predicting early (<6 hours) vs late (6–24 hours) hyperacute ischemic stroke groups. We found that lesional NAA and creatine was reduced from acute to subacute stroke patients and NAA level was inversely related to onset time in hyperacute patients. The changes in neurometabolite levels provided good discrimination between patients for early & late hyperacute time windows.

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