Abstract #0008

Quantification of Blood-Brain Barrier Water Exchange & Permeability with Multi-Delay Diffusion Weighted pCASL

Xingfeng Shao¹, Chenyang Zhao¹, Qinyang Shou¹, Keith S St Lawrence^2,3, and Danny JJ Wang¹

¹Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ²Lawson Health Research Institute, London, ON, Canada, ³Department of Medical Biophysics, Western University, London, ON, Canada

Synopsis

Keywords: YIA, Diffusion/other diffusion imaging techniques, Blood-brain barrier, water exchange, diffusion weighted perfusion imagingWe developed an innovate pulse sequence and acquired diffusion weighted pCASL signals from a wide range of PLDs with improved SNR and spatial resolution. A 3-compartment single-pass approximation (SPA) model, which includes an additional venous compartment, was proposed to capture the full dynamics of the labeled blood bolus passing through capillaries while exchanging into tissue space before flowing into venules, and a LRL method was proposed for individual kw quantification.

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