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Abstract #0011

Reproducibility of non-invasive 3D imaging of glucose downstream metabolism using deuterium labeling: indirect 1H QELT at 3T vs direct 2H DMI at 7T

Fabian Niess1, Lukas Hingerl1, Bernhard Strasser1, Petr Bednarik2,3, Dario Goranovic1, Eva Niess1, Stanislav Motyka1, Gilbert Hangel1,4, Martin Krssak5, Benjamin Spurny-Dworak6, Thomas Scherer5, Rupert Lanzenberger6, and Wolfgang Bogner1
1Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria, 2Centre for Functional and Diagnostic Imaging and Research, Danish Research Centre for Magnetic Resonance, Copenhagen, Denmark, 3Department of Radiology, University Hospital Amager and Hvidovre, Copenhagen, Denmark, 4Department of Neurosurgery, Medical University of Vienna, Vienna, Austria, 5Department of Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna, Vienna, Austria, 6Department of Psychiatry and Psychotherapy, Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, Austria

Synopsis

Keywords: Deuterium, BrainDeuterium metabolic imaging (DMI) and quantitative exchange label turnover (QELT) are emerging MR techniques to non-invasively map brain glucose uptake and downstream metabolism using safe and affordable deuterium labeled glucose as tracer. This work compares dynamically detected deuterium labeled Glutamate+Glutamine time courses between three-dimensional 3T-1H QELT-MRSI and 7T-2H-DMI using quantification of concentration estimates. Comparable enrichment of deuterated Glx could be observed in gray matter (1.59±0.24mM vs. 1.39±0.17mM) while differences were found in WM (0.89±0.32 mM vs. 1.31±0.2 mM) presumably due to partial volume contamination. Results showed a successful translation of QELT to clinical 3T.

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