Abstract #0012

Evaluation of minimal dosage of deuterated glucose for mapping of hepatic metabolism by DMI and natural abundance carbon-13 spectroscopy at 7 T

Simone Poli^1,2, Ahmed F. Emara³, Edona Ballabani³, Naomi F. Lange^4,5, Andreas Melmer³, David Herzig³, Luc Tappy³, Lia Bally³, and Roland Kreis^1,2

¹Magnetic Resonance Methodology, Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Bern, Switzerland, ²Translational Imaging Center, Sitem-insel, Bern, Switzerland, ³Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism UDEM, Inselspital, University Hospital Bern, Bern, Switzerland, ⁴Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland, ⁵Graduate School for Health Sciences, University of Bern, Bern, Switzerland

Synopsis

Keywords: Deuterium, MetabolismWe present an estimation of the minimal dose for D-glucose needed for evaluation of hepatic glucose dynamics by deuterium metabolic imaging (DMI) and investigate whether a subsequent change in hepatic glycogen content is observable by ¹³C-MRS at 7 T. Six healthy subjects received an oral glucose load of 60g, 20g or 10g and were examined with interleaved ²H-MRSI/¹³C-MRS scans for 150 min. Results suggest the feasibility of reducing D-glucose loads to as low as 10g per subject for hepatic DMI with several benefits ‑ including cost, but precision of determination of changes in hepatic glycogen content is substantially reduced.

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