Keywords: Deuterium, Deuterium
We compared the use of DMI following D2-glucose and D7-glucose ingestion in the investigation of brain metabolism in vivo. Multiple CSI measurements were acquired from five participants over ~180 minutes at 7T following ingestion of each labelled compound. D7-glucose produced significantly larger signals allowing improved mapping of the signals from labelled metabolites. Calculated time-courses of the changes in metabolite concentration in different brain tissues show significantly larger rates of increase of HDO and Glx in all tissues for D7- versus D2-glucose (e.g. in GM HDO rate of increase for D7/D2 = 0.208±0.004/0.051±0.001 mM/min and Glx rate for D7/D2 = 0.059±0.003/0.029±0.001 mM/min).
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