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Abstract #0015

Comparison of deuterium metabolic imaging measurements in human subjects at 7T following [2H2] glucose and [2H7] glucose ingestion

Daniel Cocking1,2, Robin Damion1,3,4, Elizabeth Simpson3, Paul Greenhaff3,5,6, Louise Dexter1,2, Dorothee Auer1,3,4, and Richard Bowtell1,2,3
1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, 3NIHR Nottingham Biomedical Research Centre/Nottingham Clinical Research Facilities, Queen's Medical Centre, Nottingham, United Kingdom, 4Radiological Sciences, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United Kingdom, 5MRC-Versus Arthritis Centre for Muscoskeletal Ageing Research, University of Nottingham, Nottingham, United Kingdom, 6School of Life Sciences, University of Nottingham, Nottingham, United Kingdom

Synopsis

Keywords: Deuterium, Deuterium

We compared the use of DMI following D2-glucose and D7-glucose ingestion in the investigation of brain metabolism in vivo. Multiple CSI measurements were acquired from five participants over ~180 minutes at 7T following ingestion of each labelled compound. D7-glucose produced significantly larger signals allowing improved mapping of the signals from labelled metabolites. Calculated time-courses of the changes in metabolite concentration in different brain tissues show significantly larger rates of increase of HDO and Glx in all tissues for D7- versus D2­-glucose (e.g. in GM HDO rate of increase for D7/D2 = 0.208±0.004/0.051±0.001 mM/min and Glx rate for D7/D2 = 0.059±0.003/0.029±0.001 mM/min).

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Keywords