Abstract #0021
Whole-brain bi-exponential 23Na-MRI T2* mapping at 7T with a 32-channel phased array receiver coil
Samuel Rot1,2, Jon O Cleary3, Ayse Sila Dokumaci4,5, Michael Eyre4,5,6, Philippa Bridgen5,7, Yasmin Blunck8,9, Warda Syeda10, Shaihan J Malik4,5, Joseph V Hajnal4,5, Bhavana S Solanky1,11, Shan-Shan Tang6, Claudia AM Gandini Wheeler-Kingshott1,12,13, and David Carmichael4,5
1NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, 2Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 3Department of Radiology, Imperial College Healthcare NHS Trust, London, United Kingdom, 4Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom, 5London Collaborative Ultra high field System (LoCUS), London, United Kingdom, 6Children's Neurosciences, Evelina London Children's Hospital at Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom, 7Guys and St Thomas’ NHS Foundation Trust, King's College London, London, United Kingdom, 8Department of Biomedical Engineering, The University of Melbourne, Melbourne, Australia, 9Melbourne Brain Imaging Unit, The University of Melbourne, Melbourne, Australia, 10Melbourne Neuropsychiatry Centre, The University of Melbourne, Parkville, Victoria, Australia, 11Quantitative Imaging Group, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 12Department of Brain & Behavioural Sciences, University of Pavia, Pavia, Italy, 13Brain Connectivity Centre Research Department, IRCCS Mondino Foundation, Pavia, Italy
Synopsis
Keywords: Non-Proton, Relaxometry, Sodium, T2* mappingIn vivo 23Na-MRI benefits greatly from SNR improvements at ultrahigh fields and with multi-channel receivers. Here, we report a pipeline for multi-echo radial imaging of 23Na (MERINA) at 7T, using a 32-channel receiver coil. This involves correction of image artifacts induced by gradient imperfections, followed by channel combination to maintain Rician noise distributions in combined magnitude images. This led to improved T2* mapping with a fixed-component bi-exponential signal model. T2* values (e.g. T2s*=4.6±0.9ms, T2l*=28.3±2.8ms in cerebral white matter) agree with reports in literature. Future work will involve correcting B0 inhomogeneity effects, more sophisticated signal models and exploring potential clinical applications.
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