Keywords: Alzheimer's Disease, NeuroinflammationEvidence suggests subjective cognitive decline (SCD) is an early risk factor for Alzheimer’s disease. We analyzed the associations between memory and diffusion microstructure in the lower cingulum white matter bundle in SCD with DTI and NODDI. Better memory performance was associated with decreased free water volume fraction (FWVF) in the SCD group but not the control group. To the best of our knowledge, this is the first study to find differences in the associations between NODDI FWVF and memory in SCD in the lower cingulum. This finding supports prior findings of increased neuroinflammation in the earliest stages of Alzheimer’s Disease.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords