Abstract #0026

Multiple Sclerosis (MS): High Contrast Visualisation of Abnormalities in Normal Appearing White Matter Using MASDIR Sequences

Paul Condron^1,2, Haribalan Kumar ^1,3,4, Samantha Holdsworth^1,2, Daniel Cornfeld^1,2, and Graeme Bydder^1,5

¹Mātai Medical Research Institute, Gisborne, New Zealand, ²Univeristy of Auckland, Auckland, New Zealand, ³Auckland Bioengineering Institute, Auckland, New Zealand, ⁴GE Healthcare, Victoria, Australia, ⁵University of California San Diego, San Diego, CA, United States

Synopsis

Keywords: Neuroinflammation, Multiple Sclerosis, neurodegeneration, MASDIR, Inversion Recovery (IR) sequences, tissue property filters

Keywords; Neuroinflammation, Multiple Sclerosis, Neuro, Drugs.

MASDIR sequences can show up to 15 times the contrast of T1-weighted MP-RAGE sequences. This is a consequence of using changes in T1 synergistically 3-4 times in the same sequence to detect subtle changes due to neuroinflammation and lesions. Extensive high contrast focal and diffuse abnormalities in white matter were demonstrated in areas that showed no abnormality with state-of-the-art T2-weighted spin echo and T2-FLAIR sequences in patients with multiple sclerosis. This demonstrated good correlation with advanced sequences such as T1 and myelin maps.

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