Abstract #0029

Disruption to normal excitatory and inhibitory function within the medial prefrontal cortex in patients with IBD

Jun Wang^1,2, Guangyao Liu^2,3, Kai Ai⁴, Pengfei Zhang¹, Wenjing Huang¹, and Jing Zhang^2,3

¹Second Clinical School, Lanzhou University, Lanzhou, China, ²Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, China, ³Gansu Province Clinical Research Center for Functional and Molecular Imaging, Lanzhou University Second Hospital, Lanzhou, China, ⁴Department of clinical science, Philips Healthcare, Xi’an, China

Synopsis

Keywords: Neuroinflammation, fMRI

The etiology of IBD complicated with anxiety, depression and other psychological comorbidities is still unclear. The purpose of this study was to quantify neurotransmitter (GABA and Glx) in the medial prefrontal cortex (mPFC) of IBD patients with MEGA-PRESS spectroscopy and explore its relationship with clinical scores. We found that mPFC GABA+ and Glx concentration were significantly decreased in IBD patients and were associated with abdominal pain and depressive symptoms separately, suggesting psychological comorbidities in IBD patients were related to mPFC neurotransmitter dysregulation. It provides a new explanation for the neuropsychological mechanism of IBD in the development of the disease.

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