Abstract #0030

Quantifying Cervical Spinal Cord Pathology of Multiple Sclerosis Patients Using Advanced MRI

Osman Hatipoglu^1,2,3, Tsagkas Charidimos ^1,2,3,4, Mario Ocampo-Pineda^1,2,3, Lester Melie-Garcia^1,2,3, Matthias Weigel^1,2,3,5, Po-Jui Lu^1,2,3, Muhamed Barakovic^1,2,3, Julien Cohen-Adad^6,7,8, Ludwig Kappos^2,3, Jens Kuhle^2,3, and Cristina Granziera^1,2,3

¹Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland, ²Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel and University of Basel, Basel, Switzerland, ³Neurologic Clinic and Policlinic, Departments of Head, Spine and Neuromedicine, University Hospital Basel, Basel, Switzerland, ⁴Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH), Bethesda, MD, United States, ⁵Division of Radiological Physics,Department of Radiology, University Hospital Basel, Basel, Switzerland, ⁶Functional Neuroimaging Unit, CRIUGM, Université de Montréal, Montreal, QC, Canada, ⁷NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada, ⁸Mila, Quebec AI Institute, Montreal, QC, Canada

Synopsis

Keywords: Multiple Sclerosis, Spinal Cord

The utility of advanced quantitative MRI for assessment of spinal cord tissue damage in multiple sclerosis has not yet been established. In this work, we used T1-mapping as well as quantitative magnetization transfer saturation and echo-planar imaging to quantify the extent of pathologic changes in the cervical cord of multiple sclerosis patients. Our results point to extensive demyelination and axonal loss both in the normal-appearing and lesional cervical cord, as well as to and chronic inflammation of cSCWM lesions in secondary progressive multiple sclerosis. Hence, quantitative spinal cord MRI may provide valuable information about the pathologic substrate of this disease.

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