Abstract #0032

Regional Changes in Brain Viscoelasticity in Multiple Sclerosis Assessed with Three-Dimensional MR Elastography

Ling Fang¹, Matthew C. Murphy², Sha Tan³, Qiuxia Luo¹, Jingbiao Chen¹, Bingjun He¹, Jun Chen², Jonathan M. Scott², Kevin J. Glaser², Richard L. Murphy², Wei Qiu³, and Jin Wang¹

¹Department of Radiology, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, ²Department of Radiology, Mayo Clinic, Rochester, MN, United States, ³Department of Neurology, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

Synopsis

Keywords: Multiple Sclerosis, ElastographyMultiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. MR Elastography (MRE) can quantitatively assess biomechanical tissue properties in vivo noninvasively. We investigated the potential value of MRE to reveal changes in tissue viscoelasticity in regions and the whole brain in MS patients and to analyze the relevance to clinical manifestations. Our results suggest that the damping ratio and loss modulus are promising quantitative biomarkers for evaluating tissue damage in MS.

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