Abstract #0035

Pathological Validation of Multiple Sclerosis Lesion Rims on Phase and Quantitative Susceptibility Mapping (QSM) images

Kelly M Gillen¹, Thanh D Nguyen¹, Alexey Dimov¹, Emily Demmon², Ilhami Kovanlikaya¹, Francesca Bagnato^3,4, Dominick Romano¹, David Pitt⁵, Susan Gauthier², and Yi Wang¹

¹Department of Radiology, Weill Cornell Medicine, New York, NY, United States, ²Department of Neurology, Weill Cornell Medicine, New York, NY, United States, ³Department of Neurology, TN Valley HealthCare VA Medical System, Nashville, TN, United States, ⁴4Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, ⁵Department of Neurology, Yale School of Medicine, New Haven, CT, United States

Synopsis

Keywords: Multiple Sclerosis, Quantitative Susceptibility mapping, Phase, ironMultiple Sclerosis (MS) is an autoimmune disorder characterized by focal inflammatory demyelination. Chronic MS lesions can contain chronically activated, iron-laden microglia and macrophages. By comparing rim status on quantitative susceptibility mapping (QSM) and phase imaging with histopathology that identifies iron, we demonstrate that QSM is a more reliable indicator of iron status than phase. QSM is a valuable clinical tool to identify iron positive smoldering lesions not visible using conventional MRI techniques.

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