Abstract #0038

Brain diffusion alterations in patients with COVID-19 pathology and neurological manifestations

Anna Caroli¹, Serena Capelli¹, Angela Napolitano², Giulia Cabrini³, Alberto Arrigoni¹, Giulio Pezzetti², Mattia Previtali¹, Luca Giovanni Longhi⁴, Rosalia Zangari⁵, Ferdinando Luca Lorini⁶, Maria Sessa⁷, Andrea Remuzzi³, and Simonetta Gerevini²

¹Bioengineering Department, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Ranica (BG), Italy, ²Department of Neuroradiology, ASST Papa Giovanni XXIII, Bergamo, Italy, ³University of Bergamo, Bergamo, Italy, ⁴Neurosurgical Intensive Care Unit, Department of Anesthesia and Critical Care Medicine, ASST Papa Giovanni XXIII, Bergamo, Italy, ⁵FROM Research Foundation, ASST Papa Giovanni XXIII, Bergamo, Italy, ⁶Department of Emergency and Critical Care Area, ASST Papa Giovanni XXIII, Bergamo, Italy, ⁷Department of Neurology, ASST Papa Giovanni XXIII, Bergamo, Italy

Synopsis

Keywords: Infectious disease, COVID-19This study aimed at quantifying brain diffusion alterations on DWI scans in 215 COVID-19 patients with neurological manifestations as compared with 36 normal controls. The Apparent Diffusion Coefficient (ADC) was quantified in brain tissues and regions, using an in-house MRI processing procedure. In COVID-19 patients, a widespread significant increase in ADC was found in white matter. ADC values were significantly correlated with MRI time from disease onset. ADC alteration was highest in hospitalized patients. Patients with neurological disorders showed significantly higher ADC than those with olfactory loss only. DWI shows potential as a non-invasive marker of neuroinflammation in COVID-19.

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