Abstract #0039

Total and regional brain volumes in fetuses with congenital heart disease

Daniel Cromb^1,2, Alena Uus^1,2, Milou Van Poppel³, Johannes Steinweg³, Alexandra Bonthrone^1,2, Alessandra Maggioni¹, Paul Cawley^1,4, Vanessa Kyriakopoulou¹, Jacqueline Matthew¹, Anthony Price^1,2, A David Edwards^1,2, Maria Deprez^1,2, Joseph V Hajnal^1,2, David F Lloyd^1,3,5, Kuberan Pushparajah^1,3,5, John Simpson^1,3,5, Mary Rutherford^1,4, and Serena J Counsell^1,2

¹Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ²Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ³Department of Cardiovascular Imaging, School of Biomedical Engineering & Imaging Science, King's College London, London, United Kingdom, ⁴MRC Centre for Neurodevelopmental Disorders, King's College London, London, United Kingdom, ⁵Paediatric Cardiology, Evelina London Children's Hospital, London, United Kingdom

Synopsis

Keywords: Fetal, Brain, Brain Volumes, Congenital Heart DiseaseTotal and regional brain volumes, derived from automatically segmented, motion-corrected, 3D fetal brain MR images were obtained in 45 healthy fetuses and 305 fetuses with isolated congenital heart disease (CHD) in the third trimester. Total brain tissue, cortical and deep grey matter, and white matter volumes are significantly lower in fetuses with CHD where cerebral oxygenation and substrate delivery are likely to be reduced. Brain volumes appear normal in fetuses with CHD but an otherwise expected normal cerebral oxygenation.

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