Abstract #0041

Development of Infant Brain Functional Connectome Gradients during Age 0-6 Years

Xinyi Cai¹, Lianghu Guo¹, Mianxin Liu¹, Feihong Liu¹, Jiawei Huang¹, Jiameng Liu¹, Qing Yang¹, Lang Mei¹, Tianli Tao¹, Zhuoyang Gu¹, Xiaozhao Liu¹, Yuxiao Liu¹, Xiangnan Tian¹, Qian Chen¹, Ruoming Wang¹, Yizhou Shi¹, Qian Wang¹, Han Zhang¹, and Dinggang Shen¹

¹School of Biomedical Engineering, ShanghaiTech University, Shanghai, China

Synopsis

Keywords: Normal development, Brain, Infant

Studies have revealed a particular functional connectome gradient (FC-grad) pattern in the human brain, reflecting delicate organization of brain connectome. Interestingly, the pattern can be observed along childhood-adolescent, even in neonates. However, FC-grad changes from infancy to childhood remain unraveled, with significant disparities between neonates and school-aged children not explained. We explored the early development trajectories of the FC-grads between age 0-5 years. We found that the neonatal “prototypic” connectome gradients undergoes rapid changes in this period, especially the first 12 months, reflecting maturing functional integration. Our study filled the gap of FC-grad development in early infancy.

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