Keywords: Adolescents, Neuroscience, Resting-state functional connectivityThe striatum is known to be impaired in MDD patients. Abnormal structure or function of the striatum may disturb the top-down regulation of negative emotions among persons more vulnerable to developing depressive state, especially adolescent. Here, we investigated (1) voxel-wise FC between the striatal nucleus and the whole brain; (2) region of interest wise effective connectivity using DCM analysis, according to the between-group differences in FC of the striatal nucleus. We found decreased FC in cerebello-limbic-striatal circuit, and further DCM analysis showed the dysregulation of vrPUT nucleus disturb the top-down regulation of cerebello-limbic-striatal circuit during reward processing in adolescent MDD.
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