Abstract #0047

Macrovasculature-suppressed ASL MRI in neonates: quantification of cerebral blood flow and arterial transit time

Zhiyi Hu¹, Dengrong Jiang², Jennifer Shepard³, Yuto Uchida², Kenichi Oishi², Peiying Liu^2,4, Doris Lin², Vivek Yedavalli², Aylin Tekes², W. Christopher Golden³, and Hanzhang Lu^1,2,5

¹Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, ⁵F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States

Synopsis

Keywords: Neonatal, Perfusion

A prominent feature in neonatal cerebral blood flow (CBF) measurement is the hyperperfusion in the deep brain region. Given the rich presence of large arteries in this region, it is plausible that macrovascular artifacts may play a major role in the hyperintense signals observed. This study presented a new MRI technique, pCASL with arterial suppression and flow suppression (AFS-pCASL) to minimize the macrovascular artifacts in neonates. We demonstrated that macrovascular artifacts in neonatal pCASL can be substantially suppressed, from which quantitative CBF and arterial transit time can be measured when applying the sequence in a multi-delay setting.

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