Abstract #0058

Free-Breathing Liver Iron Quantification Using 3D Stack-of-Radial GRE Dixon MRI at Two Field Strengths: A Preliminary Study

Xiaodong Zhong¹, Stephan A.R. Kannengiesser², Pedro Itriago Leon³, Vibhas Deshpande⁴, and Takeshi Yokoo⁵

¹MR R&D Collaborations, Siemens Medical Solutions USA, Inc., Los Angeles, CA, United States, ²MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany, ³MR R&D Collaborations, Siemens Medical Solutions USA, Inc., Dallas, CA, United States, ⁴MR R&D Collaborations, Siemens Medical Solutions USA, Inc., Austin, CA, United States, ⁵Department of Radiology and Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States

Synopsis

Keywords: Liver, Quantitative Imaging, R2*, Iron, LIC, free-breathingThis study compared free-breathing stack-of-radial and breath-hold Cartesian multi-echo GRE MRI for liver iron quantification at 1.5T and 3T to the reference standard R2-based liver iron concentration (LIC) at 1.5T (FerriScan), in patients at risk for liver iron overload. Agreement was observed for liver iron concentration measured by free-breathing 3D stack-of-radial GRE MRI compared the reference standard R2-based LIC, as well as breath-hold 3D Cartesian GRE MRI. With further validation in larger number of iron-overloaded subjects, 3D stack-of-radial GRE MRI may allow free-breathing R2* and LIC mapping at both 1.5T and 3T.

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