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Abstract #0059

Free-breathing Simultaneous T1, T2, and T2* Mapping of the Whole-Liver with Multi-Inversion Spin and Gradient Echo in Under a Minute

Mary Kate Manhard1,2, Anandh Kilpattu Ramaniharan1, Jean A Tkach1,2, Andrew T Trout1,2, Jonathan R Dillman1,2, and Amol Pednekar1,2
1Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 2Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States

Synopsis

Keywords: Liver, Quantitative ImagingQuantitative parametric mapping is an increasingly important tool for non-invasive assessment of liver disease. Conventional parametric mapping techniques require multiple breath-held acquisitions providing limited coverage. A free-breathing multi-inversion spin and gradient echo (MI-SAGE) technique is demonstrated to simultaneously estimate T1, T2, and T2* over the whole-liver in a single scan of less than 1 minute. In 11 research participants, hepatic T1, T2, and T2* estimates obtained using the free-breathing MI-SAGE technique were comparable to those obtained using modified Lock Locker, multiple gradient and spin echo, and multiple gradient echo sequences respectively and exhibited good to excellent (ICC>0.77) repeatability and reproducibility.

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Keywords