Keywords: Liver, RelaxometryVolumetric T1 and T2 relaxation mapping is of interest in the characterization of diffuse and oncological liver diseases. Current methods for free-breathing whole-liver relaxation mapping have primarily been optimized to quantify a water-specific T1, are restricted to large voxel sizes in the feet-head-direction, and are not compatible with self-navigation. The present work proposes a novel methodology for Free-breathing Isotropic resolution self-Navigated B1-insensitive whOle-liver simultaneous water-specific T1 and T2 mapping (FINO). Phantom results illustrate the accuracy of the method and in vivo results demonstrate the feasibility of whole-liver water-specific T1 and T2 mapping at an isotropic resolution of 3mm in 6min.
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