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Abstract #0061

Assessment of Inflammation and Spatial Heterogeneity for Nonalcoholic Fatty Liver Disease in Mice Based on Corrected T1

Lujie Li1, Kan Deng2, Yinhong Zhang1, and Shi-ting Feng1
1the First Affiliated Hospital of Sun Yet-sen University, Guangzhou, China, 2Philips Healthcare, Guangzhou, China

Synopsis

Keywords: Liver, Quantitative ImagingCorrected T1 (cT1) is potential to be a novel imaging biomarker, which was based on T1 mapping corrected for iron content. The results of this study showed the high correlation between cT1 value and NAFLD activity, without correlation with fibrosis. There was high accuracy of cT1 to identify normal liver and liver with NAFLD, as well as mild and severe NAFLD. The severer inflammation, the higher heterogeneity of cT1 mapping. Thus, cT1 may be used for evaluating liver inflammation of patient with NAFLD, especially for those without severe fibrosis, and may evaluate heterogeneity further.

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Keywords