Abstract #0062

Longitudinal MR Elastography and Proton Density Fat Fraction Measurements in Patients with Alcoholic and Nonalcoholic Fatty Liver Disease

Jiahui Li¹, Zheng Zhu¹, Kevin J. Glaser¹, Yi Sui¹, Douglas A. Simonetto², Alina M Allen², Armando Manduca¹, Sudhakar K. Venkatesh¹, Vijay H. Shah², Richard L. Ehman¹, and Meng Yin¹

¹Radiology, Mayo Clinic, Rochester, MN, United States, ²Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States

Synopsis

Keywords: Liver, LiverTo evaluate MR imaging biomarkers in monitoring chronic liver diseases, we analyzed longitudinal MRE-assessed liver stiffness (LS) and proton density fat fraction (PDFF) measurements in 46 patients with alcoholic liver disease (ALD) or nonalcoholic fatty liver disease (NAFLD). Results demonstrated that yearly LS change rate was significantly associated with current LS and PDFF change rate in NAFLD, although with low correlation (R²=0.30, p=0.01). ALD patients had bidirectional changes in LS/PDFF change rate but not significant correlation (R²=0.20, p=0.10). We conclude that longitudinal MRE-LS and MRI-PDFF provide independent and complementary assessments of disease status and dynamic change in ALD and NAFLD.

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