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Abstract #0063

Evaluation of liver fibrosis using histogram analysis with diffusion kurtosis imaging and stretched-exponential diffusion model

Fengxian Fan1, Yanli Jiang1, Jie Zou1, Pin Yang1, and Jing Zhang1
1Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, China

Synopsis

Keywords: Liver, Diffusion/other diffusion imaging techniques, histogram analysis; stretched exponential model; diffusion kurtosis imagingThis study aims to evaluate the potential role of histogram analysis of diffusion kurtosis imaging (DKI) and stretched exponential model (SEM) for preoperative prediction of liver fibrosis and inflammation. Histogram metrics were extracted from mean diffusion (MD), mean kurtosis (MK), distributed diffusion coefficient (DDC) and intravoxel heterogeneity index (α). The histogram metrics of MD, DDC and α demonstrate significant correlation with inflammation, the histogram metrics of MD and DDC were significantly different between S0-1 and ≥S2. Histogram analysis of DKI and SEM may be potentially useful for evaluating heterogeneity of liver.

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Keywords