Abstract #0065

Non-invasive evaluation of anti-integrin αvβ6 treatment of liver fibrosis by collagen-targeted MRI

Yingying Ning¹, Iris Y. Zhou¹, Nicholas J Rotile¹, Avery Boice¹, Johanna Schaub², Scott Turner², and Peter Caravan¹

¹Athinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, ²Pliant Therapeutics, Inc., South San Francisco, CA, United States

Synopsis

Keywords: Liver, Liver, liver fibrogenesisA collagen-binding molecular MR probe CM-101 was employed to non-invasively assess liver fibrosis and the anti-fibrotic effects of a novel αvβ6/αvβ1 integrin antagonist treatment in bile duct-ligated rats. Reduction of fibrosis was detected by collagen imaging and correlated with morphometric assessment of fibrosis from histology. CM-101 enhanced MR is a useful tool to monitor drug treatment response in chronic liver disease.

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