Abstract #0066

Anatomically Accurate In vitro Model of the Liver for 4D Flow MRI Validation

James Rice^1,2, Thekla Oechtering^2,3, Kevin M Johnson^2,4, Oliver Wieben^2,4, Scott B Reeder^2,4,5,6, and Alejandro Roldan-Alzate^1,2,6

¹Mechanical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ²Radiology, University of Wisconsin-Madison, Madison, WI, United States, ³Radiology, Universität zu Lübeck, Lübeck, Germany, ⁴Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ⁵Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁶Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States

Synopsis

Keywords: Liver, Modelling4D flow MRI can be used to assess hemodynamics in the hepatic circulation system. This study presents a framework for in vitro hemodynamic evaluation of hepatic flow. One patient-specific in vitro model was created representing an anatomically realistic portal vein and hepatic artery and connected to a physiologic flow loop. The model was imaged with 4D flow MRI to assess hemodynamics. Altering hepatic artery and left gastric vein resistance changed flow proportions and velocities in the portal vein, highlighting the benefit of using in vitro modeling for systematic evaluation of 4D flow MRI in the liver.

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