Abstract #0067

Quantitative Magnetization EXchange (MEX) MRI Measurement of Liver Fibrosis Model in Rodents

Ella Wilczynski¹, Efrat Sasson², Uzi Eliav², Gil Navon², and Uri Nevo^1,3

¹Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel, ²School of Chemistry, Tel Aviv University, Tel Aviv, Israel, ³Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel

Synopsis

Keywords: Liver, Preclinical, MEX

Quantitative MRI can elucidate the complex microstructural changes in liver disease. The MEX method estimates macromolecular fraction, such as collagen, and can potentially aid in this task.

Rats and mice were given CCl₄ to induce liver fibrosis and canned using a 7T scanner with MEX sequence (selective suppression and magnetization exchange) and macromolecular fraction (F) and T₁ were extracted. Histology quantitative evaluation of collagen and inflammation scoring was conducted.

F-values of fibrotic rats and mice were significantly increased and correlated with quantitative collagen percentage. T₁ was significantly elevated with higher inflammation scores.

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