Abstract #0081

Multimodal anatomical mapping of subcortical regions in Marmoset monkeys using ultra-high resolution MAP-MRI and multiple histological stains

Kadharbatcha S Saleem¹, Alexandru V Avram¹, Daniel Glen², Cecil Chern-Chyi Yen³, Vincent Schram⁴, and Peter J Basser¹

¹Section on Quantitative Imaging and Tissue Sciences (SQITS), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD-NIH), Bethesda, MD, United States, ²Scientific and Statistical Computing Core, National Institute of Mental Health (NIMH-NIH), Bethesda, MD, United States, ³Neuroimaging core, National Institute of Neurological Disorders and Stroke (NINDS-NIH), Bethesda, MD, United States, ⁴Microscopy and Imaging Core (MIC), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD-NIH), Bethesda, MD, United States

Synopsis

Keywords: Visualization, Ex-Vivo Applications, MAP-MRI, subcortical, histology, Marmoset, and diffusion MRIDespite its importance as a model for human brain development and neurological disorders, the marmoset lacks a comprehensive MRI-histology-based parcellation of subcortical regions. Here, we mapped the subcortical areas of the marmoset brain in three dimensions (3D) using ultra-high resolution MAP-MRI, T2w, and MTR imaging at 7T, combined with histological stains of the same brain. Our results demonstrate that MAP-MRI can delineate cytoarchitectonic subregions of many deep brain structures observed with histology. Tracing and validating these important brain regions in 3D are imperative for neurosurgical planning, navigation of deep brain stimulation probes, and establishing brain structure-function relationships.

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