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Abstract #0090

Microcirculation in aging skeletal muscle assessed with flow-compensated Intravoxel Incoherent Motion (IVIM)

Valentina Mazzoli1, Marco Barbieri1, Yael Vainberg1, Michelle Li 1, Matthew Middione1, Daniel B Ennis1, Feliks Kogan1, and Garry E Gold1
1Department of Radiology, Stanford University, Stanford, CA, United States

Synopsis

Keywords: Muscle, Diffusion/other diffusion imaging techniquesAssessment of microcirculation is extremely important in skeletal muscle aging reasearch. While IVIM can provide extremely valuable information on perfusion, this is usually dominated by flow in larger vessel, resulting in limited sensitivity to microcirculation. In this study we propose the use of flow and non-flow-compensated diffusion encoding waveforms for IVIM of skeletal muscle. Using this approach we show diffrences in IVIM parameters between younger and older adults, and show correlation between the difference in IVIM parameters and age

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