Abstract #0094

Contraction characteristics of the triceps surae in muscular diseases assessed by 3D dynamic imaging with synchronized electrical stimulation

Francesco Santini^1,2, Xeni Deligianni^1,2, Matteo Paoletti³, Sabrina Ravaglia³, Arianna Faggioli³, Ning Jin⁴, and Anna Pichiecchio^3,5

¹Basel Muscle MRI, Department of Biomedical Engineering, University of Basel, Basel, Switzerland, ²Research Coordination Team, Department of Radiology, University Hospital Basel, Basel, Switzerland, ³Advanced Imaging and Radiomics Center, IRCCS Mondino Foundation, Pavia, Italy, ⁴Cardiovascular MR R&D, Siemens Medical Solutions USA, Inc., Cleveland, OH, United States, ⁵Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy

Synopsis

Keywords: Muscle, Rare disease, Dynamic MRI, Muscle Function

Accelerated three-dimensional. three-directional dynamic acquisition of muscle contraction during electrical muscle stimulation was applied on a cohort of 10 patients with metabolic diseases affecting the muscles and 14 healthy controls. Maximum strain and contraction rates were calculated on the three muscles of the triceps surae.

The strain and the buildup rate (rate to reach maximum strain) showed a clear trend for the differentiation of patients and volunteers, especially in the Soleus muscle.

In conclusion, dynamic muscle MRI during electrical stimulation is a promising marker for muscle health in muscular diseases.

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